Metraipolis › archive › dc_340fd79460dc

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults — Europe PMC PMID:34014775

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/34014775
DOI: 10.1289/ehp7089
License (as archived): CC0-1.0
Archived: 2026-11-04T09:57:59.140Z
SHA-256 of the archived text: 274dd21859872ba970e7e74fdd85b0e548ecf9c955119a489d867bc6fa016cf4
Stable URL of this page: https://metraipolis.com/documento/dc_340fd79460dc

How to cite

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults — Europe PMC PMID:34014775 — Europe PMC (en), https://europepmc.org/article/MED/34014775 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_340fd79460dc (Metraipolis archive dc_340fd79460dc, sha256 274dd21859872ba970e7e74fdd85b0e548ecf9c955119a489d867bc6fa016cf4)

BibTeX

@misc{dc340fd79460dc,
  title = {Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults — Europe PMC PMID:34014775},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/34014775},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_340fd79460dc; sha256 274dd21859872ba970e7e74fdd85b0e548ecf9c955119a489d867bc6fa016cf4},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/34014775. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Chronic exposure to air pollution may prime the immune system to be reactive, increasing inflammatory responses to immune stimulation and providing a pathway to increased risk for inflammatory diseases, including asthma and cardiovascular disease. Although long-term exposure to ambient air pollution has been associated with increased circulating markers of inflammation, it is unknown whether it also relates to the magnitude of inflammatory response. Objectives: The aim of this study was to examine associations between chronic ambient pollution exposures and circulating and stimulated levels of inflammatory mediators in a cohort of healthy adults. Methods: Circulating interleukin (IL)-6, C-reactive protein (CRP) (n=392), and lipopolysaccharide stimulated production of IL-1β, IL-6, and tumor necrosis factor (TNF)-α (n=379) were measured in the Adult Health and Behavior II cohort. Fine particulate matter [particulate matter with aerodynamic diameter less than or equal to 2.5 μm (PM2.5)] and constituents [black carbon (BC), and lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe)] were estimated for each residential address using hybrid dispersion land use regression models. Associations between pollutant exposures and inflammatory measures were examined using linear regression; models were adjusted for age, sex, race, education, smoking, body mass index, and month of blood draw. Results: There were no significant correlations between circulating and stimulated measures of inflammation. Significant positive associations were found between exposure to PM2.5 and BC with stimulated production of IL-6, IL-1β, and TNF-α. Pb, Mn, Fe, and Zn exposures were positively associated with stimulated production of IL-1β and TNF-α. No pollutants were associated with circulating IL-6 or CRP levels. Discussion: Exposure to PM2.5, BC, Pb, Mn, Fe, and Zn was associated with increased production of inflammatory mediators by stimulated immune cells. In contrast, pollutant exposure was not related to circulating markers of inflammation. These results suggest that chronic exposure to some pollutants may prime immune cells to mount larger inflammatory responses, possibly contributing to increased risk for inflammatory disease. https://doi.org/10.1289/EHP7089.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2021 (prima pubblicazione 2021-05-17).
Identificativi: PMID 34014775 · PMCID PMC8136520 · DOI 10.1289/ehp7089.
Descrittori MeSH principali: Inflammation Mediators; Air Pollution; Environmental Exposure.
Pagina: https://europepmc.org/article/MED/34014775 — https://doi.org/10.1289/ehp7089. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-04T09:48:30.963Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.