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Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China — Europe PMC PMID:32997523

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32997523
DOI: 10.1289/ehp7076
License (as archived): CC0-1.0
Archived: 2026-11-07T09:29:54.640Z
SHA-256 of the archived text: 1e0b4a1e3314a41267704693f2da483c84dfc5e976127cdc1459ad4cfb3e1a4f
Stable URL of this page: https://metraipolis.com/documento/dc_330c186326d8

How to cite

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China — Europe PMC PMID:32997523 — Europe PMC (en), https://europepmc.org/article/MED/32997523 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_330c186326d8 (Metraipolis archive dc_330c186326d8, sha256 1e0b4a1e3314a41267704693f2da483c84dfc5e976127cdc1459ad4cfb3e1a4f)

BibTeX

@misc{dc330c186326d8,
  title = {Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China — Europe PMC PMID:32997523},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32997523},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_330c186326d8; sha256 1e0b4a1e3314a41267704693f2da483c84dfc5e976127cdc1459ad4cfb3e1a4f},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32997523. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. Objectives: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. Methods: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. Results: Compared with women in the lowest quartile (Q1) of individual DEP and Σ4DAP (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile (Q4) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant (p-trends<0.05). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, E2 trigger levels, and endometrial wall thickness. Conclusion: Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF. https://doi.org/10.1289/EHP7076.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2020 (prima pubblicazione 2020-09-30).
Identificativi: PMID 32997523 · PMCID PMC7526721 · DOI 10.1289/ehp7076.
Pagina: https://europepmc.org/article/MED/32997523 — https://doi.org/10.1289/ehp7076. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T09:25:32.410Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.