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Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality — Europe PMC PMID:32965128

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32965128
DOI: 10.1289/ehp6552
License (as archived): CC0-1.0
Archived: 2026-11-07T10:44:33.546Z
SHA-256 of the archived text: f5d055be92cad381fbc2688f442bdb192a5fff02218cf7b0d09f4ed9cb5ab099
Stable URL of this page: https://metraipolis.com/documento/dc_3205ff841049

How to cite

Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality — Europe PMC PMID:32965128 — Europe PMC (en), https://europepmc.org/article/MED/32965128 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_3205ff841049 (Metraipolis archive dc_3205ff841049, sha256 f5d055be92cad381fbc2688f442bdb192a5fff02218cf7b0d09f4ed9cb5ab099)

BibTeX

@misc{dc3205ff841049,
  title = {Developing a Health Impact Model for Adult Lead Exposure and Cardiovascular Disease Mortality — Europe PMC PMID:32965128},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32965128},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_3205ff841049; sha256 f5d055be92cad381fbc2688f442bdb192a5fff02218cf7b0d09f4ed9cb5ab099},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32965128. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Lead (Pb) is a highly toxic pollutant. Evidence suggests it is associated with cardiovascular disease (CVD)-related mortality. Objectives: We present a rigorous approach for identifying concentration-response functions that relate adult Pb exposures to CVD mortality to inform a health impact model (HIM). We then use the model in a proof-of-concept example. Methods: Building on previously conducted government literature reviews and a de novo supplemental literature review, we compiled and evaluated the available data on Pb and CVD mortality in humans. We applied a set of predefined selection criteria to identify studies that would be most useful in understanding the impact of Pb exposure on CVD mortality risk in adults. Once we identified the studies, we derived a HIM and used each study's concentration-response function in a proof-of-concept example. Results: Our literature search identified 15 studies for full-text review. Of those 15 studies, 4 fit our criteria for use in the HIM. Using population and CVD mortality rates for 40- to 80-y-olds in 2014, we estimated that 34,000-99,000 deaths have been avoided due to the lowering of blood Pb levels from 1999 to 2014. Based on these values we estimated that approximately 16%-46% of the decreased CVD-related death rate from 1999 to 2014 may be attributable to decreased blood Pb levels. Conclusion: Our results demonstrate that decreases in Pb exposure can result in large benefits for the adult population. We have provided a HIM that can be used in a variety of applications from burden-of-disease estimates to regulatory impact assessments and have demonstrated its sensitivity to the choice of concentration-response function. https://doi.org/10.1289/EHP6552.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2020 (prima pubblicazione 2020-09-23).
Identificativi: PMID 32965128 · PMCID PMC7510336 · DOI 10.1289/ehp6552.
Pagina: https://europepmc.org/article/MED/32965128 — https://doi.org/10.1289/ehp6552. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-07T10:39:40.972Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.