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Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera — Europe PMC PMID:33600478

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33600478
DOI: 10.1371/journal.ppat.1009270
License (as archived): CC0-1.0
Archived: 2026-11-05T21:30:24.646Z
SHA-256 of the archived text: d835d84714d8aa5af9a2061116d5e279ed48af7fe7240c9e864345f1c4116a13
Stable URL of this page: https://metraipolis.com/documento/dc_31356bbee708

How to cite

Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera — Europe PMC PMID:33600478 — Europe PMC (en), https://europepmc.org/article/MED/33600478 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_31356bbee708 (Metraipolis archive dc_31356bbee708, sha256 d835d84714d8aa5af9a2061116d5e279ed48af7fe7240c9e864345f1c4116a13)

BibTeX

@misc{dc31356bbee708,
  title = {Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera — Europe PMC PMID:33600478},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33600478},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_31356bbee708; sha256 d835d84714d8aa5af9a2061116d5e279ed48af7fe7240c9e864345f1c4116a13},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33600478. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Nosemosis C, a Nosema disease caused by microsporidia parasite Nosema ceranae, is a significant disease burden of the European honey bee Apis mellifera which is one of the most economically important insect pollinators. Nevertheless, there is no effective treatment currently available for Nosema disease and the disease mechanisms underlying the pathological effects of N. ceranae infection in honey bees are poorly understood. Iron is an essential nutrient for growth and survival of hosts and pathogens alike. The iron tug-of-war between host and pathogen is a central battlefield at the host-pathogen interface which determines the outcome of an infection, however, has not been explored in honey bees. To fill the gap, we conducted a study to investigate the impact of N. ceranae infection on iron homeostasis in honey bees. The expression of transferrin, an iron binding and transporting protein that is one of the key players of iron homeostasis, in response to N. ceranae infection was analysed. Furthermore, the functional roles of transferrin in iron homeostasis and honey bee host immunity were characterized using an RNA interference (RNAi)-based method. The results showed that N. ceranae infection causes iron deficiency and upregulation of the A. mellifera transferrin (AmTsf) mRNA in honey bees, implying that higher expression of AmTsf allows N. ceranae to scavenge more iron from the host for its proliferation and survival. The suppressed expression levels of AmTsf via RNAi could lead to reduced N. ceranae transcription activity, alleviated iron loss, enhanced immunity, and improved survival of the infected bees. The intriguing multifunctionality of transferrin illustrated in this study is a significant contribution to the existing body of literature concerning iron homeostasis in insects. The uncovered functional role of transferrin on iron homeostasis, pathogen growth and honey bee's ability to mount immune responses may hold the key for the development of novel strategies to treat or prevent diseases in honey bees.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2021 (prima pubblicazione 2021-02-18).
Identificativi: PMID 33600478 · PMCID PMC7891791 · DOI 10.1371/journal.ppat.1009270.
Descrittori MeSH principali: Host-Pathogen Interactions.
Pagina: https://europepmc.org/article/MED/33600478 — https://doi.org/10.1371/journal.ppat.1009270. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T21:27:29.840Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.