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Antiretroviral treatment failure and associated factors among people living with HIV on therapy in Homa Bay, Kenya: A retrospective study — Europe PMC PMID:36962996

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/36962996
DOI: 10.1371/journal.pgph.0001007
License (as archived): CC0-1.0
Archived: 2026-10-07T14:07:51.081Z
SHA-256 of the archived text: 7b0993da6f30a3ce1f61f56d010ba3c7121d87334591cc17cfa6954cc89ec7d9
Stable URL of this page: https://metraipolis.com/documento/dc_307dda5ee2cb

How to cite

Antiretroviral treatment failure and associated factors among people living with HIV on therapy in Homa Bay, Kenya: A retrospective study — Europe PMC PMID:36962996 — Europe PMC (en), https://europepmc.org/article/MED/36962996 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_307dda5ee2cb (Metraipolis archive dc_307dda5ee2cb, sha256 7b0993da6f30a3ce1f61f56d010ba3c7121d87334591cc17cfa6954cc89ec7d9)

BibTeX

@misc{dc307dda5ee2cb,
  title = {Antiretroviral treatment failure and associated factors among people living with HIV on therapy in Homa Bay, Kenya: A retrospective study — Europe PMC PMID:36962996},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/36962996},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_307dda5ee2cb; sha256 7b0993da6f30a3ce1f61f56d010ba3c7121d87334591cc17cfa6954cc89ec7d9},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/36962996. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Despite large numbers of patients accessing antiretroviral treatment (ART) in Kenya, few studies have explored factors associated with virologic failure in Western Kenya, specifically. We undertook a study in Homa Bay County, Kenya to assess the extent of virologic treatment failure and factors associated with it. This was an observational retrospective study conducted from September 2020 to January 2021. Data were abstracted from the records of patients who had been on ART for at least six months at the time of data collection after systematic sampling stratified by age group at ART initiation (0-14 and 15+ years), using probability proportion to the numbers of patients attending the facility. Confirmed viral treatment failure was defined as viral load ≥1000 copies/ml based on two consecutive viral load measurements after at least three months of enhanced adherence counseling. Data were analyzed using descriptive statistics and Cox regression modeling. Of the 2,007 patients sampled, 160 (8.0%) had confirmed virologic treatment failure. Significantly higher virologic treatment failure rates were identified among male patients 78/830 (9.4%) and children 115/782 (14.7%). Factors associated with virologic treatment failure (VTF), were age 0-14 years, adjusted hazard ratio (AHR) 4.42, (95% Confidence Interval [CI], 3.12, 6.32), experience of treatment side effects AHD: 2.43, (95% CI, 1.76, 3.37), attending level 2/3 health facility, AHR: 1.87, (95% CI: 1.29, 2,72), and history of opportunistic infections (OIs), AHR: 1.81, (95% CI, 1.76, 3.37). Children, attendees of level 2/3 health facilities, patients with a history of OIs, and those experiencing treatment side-effects are at risk of VTF. Increased focus on children and adolescents on screening for drug resistance, administration of and adherence to medication, and on effective information and education on side-effects is critical. Additionally, there is need for increased training and support for health care workers at primary level care facilities.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLOS global public health, 2023 (prima pubblicazione 2023-03-02).
Identificativi: PMID 36962996 · PMCID PMC10021395 · DOI 10.1371/journal.pgph.0001007.
Pagina: https://europepmc.org/article/MED/36962996 — https://doi.org/10.1371/journal.pgph.0001007. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T14:02:28.747Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.