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Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts — Europe PMC PMID:38117586

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38117586
DOI: 10.1289/ehp12831
License (as archived): CC0-1.0
Archived: 2026-10-07T11:30:21.930Z
SHA-256 of the archived text: 36b316b8c7bb1ab523ca14a5650cd33c90444c83dd0a02f7cfd4b7d099c65aa0
Stable URL of this page: https://metraipolis.com/documento/dc_2fcdae57fb00

How to cite

Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts — Europe PMC PMID:38117586 — Europe PMC (en), https://europepmc.org/article/MED/38117586 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_2fcdae57fb00 (Metraipolis archive dc_2fcdae57fb00, sha256 36b316b8c7bb1ab523ca14a5650cd33c90444c83dd0a02f7cfd4b7d099c65aa0)

BibTeX

@misc{dc2fcdae57fb00,
  title = {Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts — Europe PMC PMID:38117586},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38117586},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_2fcdae57fb00; sha256 36b316b8c7bb1ab523ca14a5650cd33c90444c83dd0a02f7cfd4b7d099c65aa0},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38117586. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Phthalate exposures are ubiquitous during pregnancy and may contribute to racial and ethnic disparities in preterm birth. Objectives: We investigated race and ethnicity in the relationship between biomarkers of phthalate exposure and preterm birth by examining: a ) how hypothetical reductions in racial and ethnic disparities in phthalate metabolites might reduce the probability of preterm birth; and b ) exposure-response models stratified by race and ethnicity. Methods: We pooled individual-level data on 6,045 pregnancies from 16 U.S. cohorts. We investigated covariate-adjusted differences in nine urinary phthalate metabolite concentrations by race and ethnicity [non-Hispanic White (White, 43%), non-Hispanic Black (Black, 13%), Hispanic/Latina (38%), and Asian/Pacific Islander (3%)]. Using g-computation, we estimated changes in the probability of preterm birth under hypothetical interventions to eliminate disparities in levels of urinary phthalate metabolites by proportionally lowering average concentrations in Black and Hispanic/Latina participants to be approximately equal to the averages in White participants. We also used race and ethnicity-stratified logistic regression to characterize associations between phthalate metabolites and preterm birth. Results: In comparison with concentrations among White participants, adjusted mean phthalate metabolite concentrations were consistently higher among Black and Hispanic/Latina participants by 23%-148% and 4%-94%, respectively. Asian/Pacific Islander participants had metabolite levels that were similar to those of White participants. Hypothetical interventions to reduce disparities in metabolite mixtures were associated with lower probabilities of preterm birth for Black [13% relative reduction; 95% confidence interval (CI): -34%, 8.6%] and Hispanic/Latina (9% relative reduction; 95% CI: -19%, 0.8%) participants. Odds ratios for preterm birth in association with phthalate metabolites demonstrated heterogeneity by race and ethnicity for two individual metabolites (mono- n -butyl and monoisobutyl phthalate), with positive associations that were larger in magnitude observed among Black or Hispanic/Latina participants. Conclusions: Phthalate metabolite concentrations differed substantially by race and ethnicity. Our results show hypothetical interventions to reduce population-level racial and ethnic disparities in biomarkers of phthalate exposure could potentially reduce the probability of preterm birth. https://doi.org/10.1289/EHP12831.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2023 (prima pubblicazione 2023-12-20).
Identificativi: PMID 38117586 · PMCID PMC10732302 · DOI 10.1289/ehp12831.
Descrittori MeSH principali: Premature Birth; Phthalic Acids; Maternal Exposure.
Pagina: https://europepmc.org/article/MED/38117586 — https://doi.org/10.1289/ehp12831. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T11:17:30.904Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.