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Impact of malaria diagnostic choice on monitoring of Plasmodium falciparum prevalence estimates in the Democratic Republic of the Congo and relevance to… — Europe PMC PMID:37494361

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37494361
DOI: 10.1371/journal.pgph.0001375
License (as archived): CC0-1.0
Archived: 2026-10-07T12:57:47.967Z
SHA-256 of the archived text: 836785e5d1bf0ff1c492d7ef8aa225810486dcb890b0a578a8f25ab2bc7404e6
Stable URL of this page: https://metraipolis.com/documento/dc_2eb29f280bf9

How to cite

Impact of malaria diagnostic choice on monitoring of Plasmodium falciparum prevalence estimates in the Democratic Republic of the Congo and relevance to… — Europe PMC PMID:37494361 — Europe PMC (en), https://europepmc.org/article/MED/37494361 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_2eb29f280bf9 (Metraipolis archive dc_2eb29f280bf9, sha256 836785e5d1bf0ff1c492d7ef8aa225810486dcb890b0a578a8f25ab2bc7404e6)

BibTeX

@misc{dc2eb29f280bf9,
  title = {Impact of malaria diagnostic choice on monitoring of Plasmodium falciparum prevalence estimates in the Democratic Republic of the Congo and relevance to… — Europe PMC PMID:37494361},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37494361},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_2eb29f280bf9; sha256 836785e5d1bf0ff1c492d7ef8aa225810486dcb890b0a578a8f25ab2bc7404e6},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37494361. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Malaria programs rely upon a variety of diagnostic assays, including rapid diagnostic tests (RDTs), microscopy, polymerase chain reaction (PCR), and bead-based immunoassays (BBA), to monitor malaria prevalence and support control and elimination efforts. Data comparing these assays are limited, especially from high-burden countries like the Democratic Republic of the Congo (DRC). Using cross-sectional and routine data, we compared diagnostic performance and Plasmodium falciparum prevalence estimates across health areas of varying transmission intensity to illustrate the relevance of assay performance to malaria control programs. Data and samples were collected between March-June 2018 during a cross-sectional household survey across three health areas with low, moderate, and high transmission intensities within Kinshasa Province, DRC. Samples from 1,431 participants were evaluated using RDT, microscopy, PCR, and BBA. P. falciparum parasite prevalence varied between diagnostic methods across all health areas, with the highest prevalence estimates observed in Bu (57.4-72.4% across assays), followed by Kimpoko (32.6-53.2%), and Voix du Peuple (3.1-8.4%). Using latent class analysis to compare these diagnostic methods against an "alloyed gold standard," the most sensitive diagnostic method was BBA in Bu (high prevalence) and Voix du Peuple (low prevalence), while PCR diagnosis was most sensitive in Kimpoko (moderate prevalence). RDTs were consistently the most specific diagnostic method in all health areas. Among 9.0 million people residing in Kinshasa Province in 2018, the estimated P. falciparum prevalence by microscopy, PCR, and BBA were nearly double that of RDT. Comparison of malaria RDT, microscopy, PCR, and BBA results confirmed differences in sensitivity and specificity that varied by endemicity, with PCR and BBA performing best for detecting any P. falciparum infection. Prevalence estimates varied widely depending on assay type for parasite detection. Inherent differences in assay performance should be carefully considered when using community survey and surveillance data to guide policy decisions.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLOS global public health, 2023 (prima pubblicazione 2023-07-26).
Identificativi: PMID 37494361 · PMCID PMC10370698 · DOI 10.1371/journal.pgph.0001375.
Pagina: https://europepmc.org/article/MED/37494361 — https://doi.org/10.1371/journal.pgph.0001375. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T12:28:09.518Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.