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Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C) — Europe PMC PMID:33720955

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33720955
DOI: 10.1371/journal.pone.0247080
License (as archived): CC0-1.0
Archived: 2026-11-05T14:03:08.881Z
SHA-256 of the archived text: 3d39aba0ea67fb17b7817b4a6810e6c9294041be15d07e89d6924f5757c30a00
Stable URL of this page: https://metraipolis.com/documento/dc_28ca8a536fc6

How to cite

Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C) — Europe PMC PMID:33720955 — Europe PMC (en), https://europepmc.org/article/MED/33720955 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_28ca8a536fc6 (Metraipolis archive dc_28ca8a536fc6, sha256 3d39aba0ea67fb17b7817b4a6810e6c9294041be15d07e89d6924f5757c30a00)

BibTeX

@misc{dc28ca8a536fc6,
  title = {Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C) — Europe PMC PMID:33720955},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33720955},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_28ca8a536fc6; sha256 3d39aba0ea67fb17b7817b4a6810e6c9294041be15d07e89d6924f5757c30a00},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33720955. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Campylobacter is one of the major foodborne pathogens causing bacterial gastroenteritis worldwide. The immune response of broiler chickens to C. jejuni is under-researched. This study aimed to characterize the immune response of chickens to Campylobacter jejuni colonization. Birds were challenged orally with 0.5 mL of 2.4 x 108 CFU/mL of Campylobacter jejuni or with 0.5 mL of 0.85% saline. Campylobacter jejuni persisted in the ceca of challenged birds with cecal colonization reaching 4.9 log10 CFU/g on 21 dpi. Campylobacter was disseminated to the spleen and liver on 7 dpi and was cleared on 21 dpi from both internal organs. Challenged birds had a significant increase in anti-Campylobacter serum IgY (14&21 dpi) and bile IgA (14 dpi). At 3 dpi, there was a significant suppression in T-lymphocytes derived from the cecal tonsils of birds in the challenge treatment when compared to the control treatment after 72 h of ex vivo stimulation with Con A or C. jejuni. The T-cell suppression on 3 dpi was accompanied by a significant decrease in LITAF, K60, CLAU-2, IL-1β, iNOS, and IL-6 mRNA levels in the ceca and an increase in nitric oxide production from adherent splenocytes of challenged birds. In addition, on 3 dpi, there was a significant increase in CD4+ and CD8+ T lymphocytes in the challenge treatment. On 14 dpi, both pro and anti-inflammatory cytokines were upregulated in the spleen, and a significant increase in CD8+ T lymphocytes in Campylobacter-challenged birds' ceca was observed. The persistence of C. jejuni in the ceca of challenged birds on 21 dpi was accompanied by an increase in IL-10 and LITAF mRNA levels, an increase in MNC proliferation when stimulated ex-vivo with the diluted C. jejuni, an increase in serum specific IgY antibodies, an increase in both CD4+ and CD8+ cells, and a decrease in CD4+:CD8+ cell ratio. The balanced Th1 and Th2 immune responses against C. jejuni might explain the ceca's bacterial colonization and the absence of pathology in Campylobacter-challenged birds. Future studies on T lymphocyte subpopulations should elucidate a pivotal role in the persistence of Campylobacter in the ceca.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2021 (prima pubblicazione 2021-03-15).
Identificativi: PMID 33720955 · PMCID PMC7959354 · DOI 10.1371/journal.pone.0247080.
Pagina: https://europepmc.org/article/MED/33720955 — https://doi.org/10.1371/journal.pone.0247080. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T14:00:27.964Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.