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Incident prolonged QT interval in midlife and late-life cognitive performance — Europe PMC PMID:32097438

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/32097438
DOI: 10.1371/journal.pone.0229519
License (as archived): CC0-1.0
Archived: 2026-11-09T09:38:09.140Z
SHA-256 of the archived text: c2ab17a8f5b79ce612a0e5b9c5bd3dc2a9f9c96bd43f7da2165fcddf5609b51c
Stable URL of this page: https://metraipolis.com/documento/dc_23bbfffef197

How to cite

Incident prolonged QT interval in midlife and late-life cognitive performance — Europe PMC PMID:32097438 — Europe PMC (en), https://europepmc.org/article/MED/32097438 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_23bbfffef197 (Metraipolis archive dc_23bbfffef197, sha256 c2ab17a8f5b79ce612a0e5b9c5bd3dc2a9f9c96bd43f7da2165fcddf5609b51c)

BibTeX

@misc{dc23bbfffef197,
  title = {Incident prolonged QT interval in midlife and late-life cognitive performance — Europe PMC PMID:32097438},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/32097438},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_23bbfffef197; sha256 c2ab17a8f5b79ce612a0e5b9c5bd3dc2a9f9c96bd43f7da2165fcddf5609b51c},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/32097438. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Measures of cardiac ventricular electrophysiology have been associated with cognitive performance in cross-sectional studies. We sought to evaluate the association of worsening ventricular repolarization in midlife, as measured by incident prolonged QT interval, with cognitive decline in late life. Methods: Midlife QT interval was assessed by electrocardiography during three study visits from 1965/68 to 1971/74 in a cohort of Japanese American men aged 46-68 at Exam 1 from the Honolulu Heart Study. We defined incident prolonged QT as the QT interval in the upper quartile at Exam 2 or 3 after QT interval in lower three quartiles at Exam 1. Cognitive performance was assessed at least once using the Cognitive Abilities Screening Instrument (CASI), scored using item response theory (CASI-IRT), during four subsequent visits from 1991/93 to 1999/2000 among 2,511 of the 4,737 men in the Honolulu-Asia Aging Study otherwise eligible for inclusion in analyses. We used marginal structural modeling to determine the association of incident prolonged QT with cognitive decline, using weighting to account for confounding and attrition. Results: Incident prolonged QT interval in midlife was not associated with late-life CASI-IRT at cognitive baseline (estimated difference in CASI-IRT: 0.04; 95% CI: -0.28, 0.35; p = 0.81), or change in CASI-IRT over time (estimated difference in annual change in CASI-IRT: -0.002; 95%CI: -0.013, 0.010; p = 0.79). Findings were consistent across sensitivity analyses. Conclusions: Although many midlife cardiovascular risk factors and cardiac structure and function measures are associated with late-life cognitive decline, incident prolonged QT interval in midlife was not associated with late-life cognitive performance or cognitive decline.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2020 (prima pubblicazione 2020-02-25).
Identificativi: PMID 32097438 · PMCID PMC7041789 · DOI 10.1371/journal.pone.0229519.
Pagina: https://europepmc.org/article/MED/32097438 — https://doi.org/10.1371/journal.pone.0229519. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-09T09:32:24.288Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.