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Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning — Europe PMC PMID:31765413

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31765413
DOI: 10.1371/journal.pone.0225188
License (as archived): CC0-1.0
Archived: 2026-11-10T00:55:39.927Z
SHA-256 of the archived text: fe6f9afa8e0bf680b9d0bf8763794aae12f7fd99df061d161024d98a02d11481
Stable URL of this page: https://metraipolis.com/documento/dc_2162dca5bfe1

How to cite

Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning — Europe PMC PMID:31765413 — Europe PMC (en), https://europepmc.org/article/MED/31765413 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_2162dca5bfe1 (Metraipolis archive dc_2162dca5bfe1, sha256 fe6f9afa8e0bf680b9d0bf8763794aae12f7fd99df061d161024d98a02d11481)

BibTeX

@misc{dc2162dca5bfe1,
  title = {Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning — Europe PMC PMID:31765413},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31765413},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_2162dca5bfe1; sha256 fe6f9afa8e0bf680b9d0bf8763794aae12f7fd99df061d161024d98a02d11481},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31765413. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Rare diseases defined by genetic mutations are classic targets for gene therapy. More recently, researchers expanded the use of gene therapy in non-clinical studies to infectious diseases through the delivery of vectorized antibodies to well-defined antigens. Here, we further extend the utility of gene therapy beyond the "accepted" indications to include organophosphate poisoning. There are no approved preventives for the multi-organ damage resulting from acute or chronic exposure to organophosphates. We show that a single intramuscular injection of adeno-associated virus vector produces peak expression (~0.5 mg/ml) of active human butyrylcholinesterase (hBChE) in mice serum within 3-4 weeks post-treatment. This expression is sustained for up to 140 days post-injection with no silencing. Sustained expression of hBChE provided dose-dependent protection against VX in male and female mice despite detectable antibodies to hBChE in some mice, thereby demonstrating that expression of hBChE in vivo in mouse muscle is an effective prophylactic against organophosphate poisoning.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-11-25).
Identificativi: PMID 31765413 · PMCID PMC6876934 · DOI 10.1371/journal.pone.0225188.
Pagina: https://europepmc.org/article/MED/31765413 — https://doi.org/10.1371/journal.pone.0225188. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-10T00:52:26.426Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.