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Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant — Europe PMC PPR:PPR334689

Source: Europe PMC
Original: https://europepmc.org/article/PPR/PPR334689
DOI: 10.1101/2021.05.05.442780
License (as archived): CC0-1.0
Archived: 2026-11-04T12:59:31.804Z
SHA-256 of the archived text: 78029f4afdd6c7b011afe1b28a5a8d771947c71dbdfbf224f4f576bafd0ba985
Stable URL of this page: https://metraipolis.com/documento/dc_1a43f6eee00a

How to cite

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant — Europe PMC PPR:PPR334689 — Europe PMC, https://europepmc.org/article/PPR/PPR334689 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_1a43f6eee00a (Metraipolis archive dc_1a43f6eee00a, sha256 78029f4afdd6c7b011afe1b28a5a8d771947c71dbdfbf224f4f576bafd0ba985)

BibTeX

@misc{dc1a43f6eee00a,
  title = {Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant — Europe PMC PPR:PPR334689},
  howpublished = {Europe PMC},
  url = {https://europepmc.org/article/PPR/PPR334689},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_1a43f6eee00a; sha256 78029f4afdd6c7b011afe1b28a5a8d771947c71dbdfbf224f4f576bafd0ba985},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC, https://europepmc.org/article/PPR/PPR334689. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

The circulation of SARS-CoV-2 has resulted in the emergence of variants of concern (VOCs). It is currently unclear whether previous infection with SARS-CoV-2 provides protection against reinfection with VOCs. Here, we show that low dose aerosol exposure to hCoV-19/human/USA/WA-CDC-WA1/2020 (WA1, lineage A), resulted in a productive mild infection. In contrast, low dose of SARS-CoV-2 via fomites did not result in productive infection in the majority of exposed hamsters and these animals remained non-seroconverted. After recovery, hamsters were re-exposed to hCoV-19/South African/KRISP-K005325/2020 (VOC B.1.351) via an intranasal challenge. Seroconverted rechallenged animals did not lose weight and shed virus for 3 days. They had little infectious virus and no pathology in the lungs. In contrast, shedding, weight loss and extensive pulmonary pathology caused by B.1.351 replication was observed in the non-seroconverted animals. The rechallenged seroconverted animals did not transmit virus to naïve sentinels via direct contact transmission, in contrast to the non-seroconverted animals. Reinfection with B.1.351 triggered an anamnestic response that boosted not only neutralizing titers against lineage A, but also titers against B.1.351. Our results confirm that aerosol exposure is a more efficient infection route than fomite exposure. Furthermore, initial infection with SARS-CoV-2 lineage A does not prevent heterologous reinfection with B.1.351 but prevents disease and onward transmission. These data suggest that previous SARS-CoV-2 exposure induces partial protective immunity. The reinfection generated a broadly neutralizing humoral response capable of effectively neutralizing B.1.351 while maintaining its ability to neutralize the virus to which the initial response was directed against.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: bioRxiv, 2021 (prima pubblicazione 2021-05-05).
Identificativi: DOI 10.1101/2021.05.05.442780.
Pagina: https://europepmc.org/article/PPR/PPR334689 — https://doi.org/10.1101/2021.05.05.442780. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-04T12:35:08.577Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.