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Antibacterial activities of Miang extracts against selected pathogens and the potential of the tannin-free extracts in the growth inhibition of Streptococcus… — Europe PMC PMID:38718045

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/38718045
DOI: 10.1371/journal.pone.0302717
License (as archived): CC0-1.0
Archived: 2026-10-06T18:46:18.662Z
SHA-256 of the archived text: 4d9c4c3bc2aa583074691bb7190656b20da1c9b0f409d33dfa03e2a28c6b21e0
Stable URL of this page: https://metraipolis.com/documento/dc_17160488ecce

How to cite

Antibacterial activities of Miang extracts against selected pathogens and the potential of the tannin-free extracts in the growth inhibition of Streptococcus… — Europe PMC PMID:38718045 — Europe PMC (en), https://europepmc.org/article/MED/38718045 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_17160488ecce (Metraipolis archive dc_17160488ecce, sha256 4d9c4c3bc2aa583074691bb7190656b20da1c9b0f409d33dfa03e2a28c6b21e0)

BibTeX

@misc{dc17160488ecce,
  title = {Antibacterial activities of Miang extracts against selected pathogens and the potential of the tannin-free extracts in the growth inhibition of Streptococcus… — Europe PMC PMID:38718045},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/38718045},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_17160488ecce; sha256 4d9c4c3bc2aa583074691bb7190656b20da1c9b0f409d33dfa03e2a28c6b21e0},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/38718045. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Bacterial pathogens have remained a major public health concern for several decades. This study investigated the antibacterial activities of Miang extracts (at non-neutral and neutral pH) against Bacillus cereus TISTR 747, Escherichia coli ATCC 22595, Salmonella enterica serovar Typhimurium TISTR 292 and Streptococcus mutans DMST 18777. The potential of Polyvinylpolypyrrolidone (PVPP)-precipitated tannin-free Miang extracts in growth-inhibition of the cariogenic Streptococcus mutans DMST 18777 and its biofilms was also evaluated. The tannin-rich fermented extracts had the best bacterial growth inhibition against S. mutans DMST 18777 with an MIC of 0.29 and 0.72 mg/mL for nonfilamentous fungi (NFP) Miang and filamentous-fungi-processed (FFP) Miang respectively. This observed anti-streptococcal activity still remained after PVPP-mediated precipitation of bioactive tannins especially, in NFP and FFP Miang. Characterization of the PVPP-treated extracts using High performance liquid chromatography quadrupole-time of flight-mass spectrometry (HPLC-QToF-MS) analysis, also offered an insight into probable compound classes responsible for the activities. In addition, Crystal violet-staining also showed better IC50 values for NFP Miang (4.30 ± 0.66 mg/mL) and FFP Miang (12.73 ± 0.11 mg/mL) against S. mutans DMST 18777 biofilms in vitro. Homology modeling and molecular docking analysis using HPLC-MS identified ligands in tannin-free Miang supernatants, was performed against modelled S. mutans DMST 18777 sortase A enzyme. The in silico analysis suggested that the inhibition by NFP and FFP Miang might be attributed to the presence of ellagic acid, flavonoid aglycones, and glycosides. Thus, these Miang extracts could be optimized and explored as natural active pharmaceutical ingredients (NAPIs) for applications in oral hygienic products.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2024 (prima pubblicazione 2024-05-08).
Identificativi: PMID 38718045 · PMCID PMC11078415 · DOI 10.1371/journal.pone.0302717.
Descrittori MeSH principali: Biofilms; Streptococcus mutans; Tannins; Plant Extracts; Anti-Bacterial Agents; Microbial Sensitivity Tests; Molecular Docking Simulation.
Pagina: https://europepmc.org/article/MED/38718045 — https://doi.org/10.1371/journal.pone.0302717. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T17:12:53.151Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.