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Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity — Europe PMC PMID:40928347

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40928347
DOI: 10.7554/elife.101578
License (as archived): CC0-1.0
Archived: 2026-10-07T23:20:22.592Z
SHA-256 of the archived text: fea6ffe1443b41b070a6f91a04a199695d871f70aa7697c2c75e1c54b5470a6f
Stable URL of this page: https://metraipolis.com/documento/dc_14720232dbda

How to cite

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity — Europe PMC PMID:40928347 — Europe PMC (en), https://europepmc.org/article/MED/40928347 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_14720232dbda (Metraipolis archive dc_14720232dbda, sha256 fea6ffe1443b41b070a6f91a04a199695d871f70aa7697c2c75e1c54b5470a6f)

BibTeX

@misc{dc14720232dbda,
  title = {Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity — Europe PMC PMID:40928347},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40928347},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_14720232dbda; sha256 fea6ffe1443b41b070a6f91a04a199695d871f70aa7697c2c75e1c54b5470a6f},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40928347. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Human cytomegalovirus (HCMV) infects up to 80% of the world's population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses reveal HCMV-induced perturbation of Hippo signaling through drastic reduction of TEAD1 transcription factor activity. We confirm extensive concordant loss of TEAD1 binding, active H3K27ac histone marks, and chromatin looping interactions upon infection. Our data position TEAD1 at the top of a hierarchy involving multiple altered important developmental pathways. HCMV infection reduces TEAD1 activity through four distinct mechanisms: closing of TEAD1-bound chromatin, reduction of YAP1 and phosphorylated YAP1 levels, reduction of TEAD1 transcript and protein levels, and alteration of TEAD1 exon 6 usage. Altered TEAD1-based mechanisms are highly enriched at genetic risk loci associated with eye and ear development, providing mechanistic insight into HCMV's established roles in these processes.

Tema degli esploratori: ricerca e scienza aperta (ricerca Europe PMC «preprint», solo open access).
Pubblicazione: eLife, 2025 (prima pubblicazione 2025-09-10).
Identificativi: PMID 40928347 · PMCID PMC12422734 · DOI 10.7554/elife.101578.
Parole chiave degli autori: Human; Viruses; Microbiology; Gene regulation; Infectious disease; Functional genomics; Virus infection; Cytomegalovirus; Epigenetics; chromosomes; Gene Expression.
Descrittori MeSH principali: Chromatin; Cytomegalovirus; Cytomegalovirus Infections; DNA-Binding Proteins; Nuclear Proteins; Transcription Factors; Host-Pathogen Interactions.
Pagina: https://europepmc.org/article/MED/40928347 — https://doi.org/10.7554/elife.101578. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T22:57:29.830Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.