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Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections — Europe PMC PMID:33513191

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33513191
DOI: 10.1371/journal.ppat.1009240
License (as archived): CC0-1.0
Archived: 2026-11-06T02:28:01.257Z
SHA-256 of the archived text: 366dd4f900abc63f1e5c3f18ffbddd85d6907c54e5332c9a7e6d219b9e0369c2
Stable URL of this page: https://metraipolis.com/documento/dc_0f91affbc2cf

How to cite

Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections — Europe PMC PMID:33513191 — Europe PMC (en), https://europepmc.org/article/MED/33513191 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_0f91affbc2cf (Metraipolis archive dc_0f91affbc2cf, sha256 366dd4f900abc63f1e5c3f18ffbddd85d6907c54e5332c9a7e6d219b9e0369c2)

BibTeX

@misc{dc0f91affbc2cf,
  title = {Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections — Europe PMC PMID:33513191},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33513191},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_0f91affbc2cf; sha256 366dd4f900abc63f1e5c3f18ffbddd85d6907c54e5332c9a7e6d219b9e0369c2},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33513191. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Dengue human infection studies present an opportunity to address many longstanding questions in the field of flavivirus biology. However, limited data are available on how the immunological and transcriptional response elicited by an attenuated challenge virus compares to that associated with a wild-type DENV infection. To determine the kinetic transcriptional signature associated with experimental primary DENV-1 infection and to assess how closely this profile correlates with the transcriptional signature accompanying natural primary DENV-1 infection, we utilized scRNAseq to analyze PBMC from individuals enrolled in a DENV-1 human challenge study and from individuals experiencing a natural primary DENV-1 infection. While both experimental and natural primary DENV-1 infection resulted in overlapping patterns of inflammatory gene upregulation, natural primary DENV-1 infection was accompanied with a more pronounced suppression in gene products associated with protein translation and mitochondrial function, principally in monocytes. This suggests that the immune response elicited by experimental and natural primary DENV infection are similar, but that natural primary DENV-1 infection has a more pronounced impact on basic cellular processes to induce a multi-layered anti-viral state.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2021 (prima pubblicazione 2021-01-29).
Identificativi: PMID 33513191 · PMCID PMC7875406 · DOI 10.1371/journal.ppat.1009240.
Descrittori MeSH principali: Gene Expression Regulation.
Pagina: https://europepmc.org/article/MED/33513191 — https://doi.org/10.1371/journal.ppat.1009240. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-06T02:25:11.617Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.