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Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli and ESBL Genes among Children and Domestic Animals in Ecuador — Europe PMC PMID:33617318

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33617318
DOI: 10.1289/ehp7729
License (as archived): CC0-1.0
Archived: 2026-11-05T20:38:09.731Z
SHA-256 of the archived text: 4cbd178d54c590e2f75afb7962b18c94425ce301ea31c68315c6ceea9b654e08
Stable URL of this page: https://metraipolis.com/documento/dc_0eb1783bb360

How to cite

Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli and ESBL Genes among Children and Domestic Animals in Ecuador — Europe PMC PMID:33617318 — Europe PMC (en), https://europepmc.org/article/MED/33617318 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_0eb1783bb360 (Metraipolis archive dc_0eb1783bb360, sha256 4cbd178d54c590e2f75afb7962b18c94425ce301ea31c68315c6ceea9b654e08)

BibTeX

@misc{dc0eb1783bb360,
  title = {Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli and ESBL Genes among Children and Domestic Animals in Ecuador — Europe PMC PMID:33617318},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33617318},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_0eb1783bb360; sha256 4cbd178d54c590e2f75afb7962b18c94425ce301ea31c68315c6ceea9b654e08},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33617318. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: There is a significant gap in our understanding of the sources of multidrug-resistant bacteria and resistance genes in community settings where human-animal interfaces exist. Objectives: This study characterized the relationship of third-generation cephalosporin-resistant Escherichia coli (3GCR-EC) isolated from animal feces in the environment and child feces based on phenotypic antimicrobial resistance (AMR) and whole genome sequencing (WGS). Methods: We examined 3GCR-EC isolated from environmental fecal samples of domestic animals and child fecal samples in Ecuador. We analyzed phenotypic and genotypic AMR, as well as clonal relationships (CRs) based on pairwise single-nucleotide polymorphisms (SNPs) analysis of 3GCR-EC core genomes. CRs were defined as isolates with fewer than 100 different SNPs. Results: A total of 264 3GCR-EC isolates from children (n=21), dogs (n=20), and chickens (n=18) living in the same region of Quito, Ecuador, were identified. We detected 16 CRs total, which were found between 7 children and 5 domestic animals (5 CRs) and between 19 domestic animals (11 CRs). We observed that several clonally related 3GCR-EC isolates had acquired different plasmids and AMR genes. Most CRs were observed in different homes (n=14) at relatively large distances. Isolates from children and domestic animals shared the same blaCTX-M allelic variants, and the most prevalent were blaCTX-M-55 and blaCTX-M-65, which were found in isolates from children, dogs, and chickens. Discussion: This study provides evidence of highly dynamic horizontal transfer of AMR genes and mobile genetic elements (MGEs) in the E. coli community and shows that some 3GCR-EC and (extended-spectrum β-lactamase) ESBL genes may have moved relatively large distances among domestic animals and children in semirural communities near Quito, Ecuador. Child-animal contact and the presence of domestic animal feces in the environment potentially serve as important sources of drug-resistant bacteria and ESBL genes. https://doi.org/10.1289/EHP7729.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: Environmental health perspectives, 2021 (prima pubblicazione 2021-02-22).
Identificativi: PMID 33617318 · PMCID PMC7899495 · DOI 10.1289/ehp7729.
Descrittori MeSH principali: Escherichia coli; Escherichia coli Infections.
Pagina: https://europepmc.org/article/MED/33617318 — https://doi.org/10.1289/ehp7729. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T20:34:51.356Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.