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Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors — Europe PMC PMID:40047526

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40047526
DOI: 10.7554/elife.103259
License (as archived): CC0-1.0
Archived: 2026-10-06T13:17:40.027Z
SHA-256 of the archived text: 6f30e60ed99cc218f7b7dde36969d851fd35b67fd1326d313c77f870991b38fd
Stable URL of this page: https://metraipolis.com/documento/dc_0b80368eb501

How to cite

Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors — Europe PMC PMID:40047526 — Europe PMC (en), https://europepmc.org/article/MED/40047526 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_0b80368eb501 (Metraipolis archive dc_0b80368eb501, sha256 6f30e60ed99cc218f7b7dde36969d851fd35b67fd1326d313c77f870991b38fd)

BibTeX

@misc{dc0b80368eb501,
  title = {Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors — Europe PMC PMID:40047526},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40047526},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_0b80368eb501; sha256 6f30e60ed99cc218f7b7dde36969d851fd35b67fd1326d313c77f870991b38fd},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40047526. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

RNA-binding proteins (RBPs) perform diverse functions including the regulation of chromatin dynamics and the coupling of transcription with RNA processing. However, our understanding of their actions in mammalian neurons remains limited. Using affinity purification, yeast-two-hybrid and proximity ligation assays, we identified interactions of multiple RBPs with neural retina leucine (NRL) zipper, a Maf-family transcription factor critical for retinal rod photoreceptor development and function. In addition to splicing, many NRL-interacting RBPs are associated with R-loops, which form during transcription and increase during photoreceptor maturation. Focusing on DHX9 RNA helicase, we demonstrate that its expression is modulated by NRL and that the NRL-DHX9 interaction is positively influenced by R-loops. ssDRIP-Seq analysis reveals both stranded and unstranded R-loops at distinct genomic elements, characterized by active and inactive epigenetic signatures and enriched at neuronal genes. NRL binds to both types of R-loops, suggesting an epigenetically independent function. Our findings suggest additional functions of NRL during transcription and highlight complex interactions among transcription factors, RBPs, and R-loops in regulating photoreceptor gene expression in the mammalian retina.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2025 (prima pubblicazione 2025-03-06).
Identificativi: PMID 40047526 · PMCID PMC11884789 · DOI 10.7554/elife.103259.
Parole chiave degli autori: Genetics; Mouse; RNA-binding protein; Genomics; Protein interaction; Gene Expression; Retinal Development.
Descrittori MeSH principali: RNA-Binding Proteins; Eye Proteins; Basic-Leucine Zipper Transcription Factors; Retinal Rod Photoreceptor Cells.
Pagina: https://europepmc.org/article/MED/40047526 — https://doi.org/10.7554/elife.103259. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T11:32:36.083Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.