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Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice — Europe PMC PMID:27325568

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/27325568
DOI: 10.1289/ehp164
License (as archived): CC0-1.0
Archived: 2026-10-08T01:33:25.612Z
SHA-256 of the archived text: 23e184215610160aac05665dfa05362832df9f00c942b591064aa0520178a2b4
Stable URL of this page: https://metraipolis.com/documento/dc_08254ea1acea

How to cite

Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice — Europe PMC PMID:27325568 — Europe PMC (en), https://europepmc.org/article/MED/27325568 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_08254ea1acea (Metraipolis archive dc_08254ea1acea, sha256 23e184215610160aac05665dfa05362832df9f00c942b591064aa0520178a2b4)

BibTeX

@misc{dc08254ea1acea,
  title = {Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice — Europe PMC PMID:27325568},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/27325568},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_08254ea1acea; sha256 23e184215610160aac05665dfa05362832df9f00c942b591064aa0520178a2b4},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/27325568. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, the use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans. Objective: We hypothesized that perinatal DDT exposure causes hypertension in adult mice. Methods: DDT was administered to C57BL/6J dams from gestational day 11.5 to postnatal day 5. Blood pressure (BP) and myocardial wall thickness were measured in male and female adult offspring. Adult mice were treated with an angiotensin converting enzyme (ACE) inhibitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition. We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP through renal ion transport. Results: Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increased myocardial wall thickness, and elevated expression of mRNAs of several renal ion transporters. Captopril completely reversed hypertension in mice perinatally exposed to DDT. Conclusions: These data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult offspring. A key mechanism underpinning this hypertension is an overactivated renin angiotensin system because ACE inhibition reverses the hypertension induced by perinatal DDT exposure. Citation: La Merrill M, Sethi S, Benard L, Moshier E, Haraldsson B, Buettner C. 2016. Perinatal DDT exposure induces hypertension and cardiac hypertrophy in adult mice. Environ Health Perspect 124:1722-1727; http://dx.doi.org/10.1289/EHP164.

Tema degli esploratori: finanziamenti e grant (ricerca Europe PMC «venture capital», solo open access).
Pubblicazione: Environmental health perspectives, 2016 (prima pubblicazione 2016-06-21).
Identificativi: PMID 27325568 · PMCID PMC5089878 · DOI 10.1289/ehp164.
Descrittori MeSH principali: Environmental Exposure.
Pagina: https://europepmc.org/article/MED/27325568 — https://doi.org/10.1289/ehp164. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T01:07:52.433Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.