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Statistical coupling analysis — Wikipedia (en)

Source: Wikipedia (en)
Original: https://en.wikipedia.org/wiki/Statistical_coupling_analysis
License (as archived): CC-BY-SA-4.0
Archived: 2026-10-07T23:59:46.648Z
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Statistical coupling analysis — Wikipedia (en) — Wikipedia (en), https://en.wikipedia.org/wiki/Statistical_coupling_analysis (CC-BY-SA-4.0); archived copy: https://metraipolis.com/documento/dc_07b7828f4e8c (Metraipolis archive dc_07b7828f4e8c, sha256 7238ead4e073e0d894b72995174ef6695b6b93da9d1517965998829b1b7a8cd6)

BibTeX

@misc{dc07b7828f4e8c,
  title = {Statistical coupling analysis — Wikipedia (en)},
  howpublished = {Wikipedia (en)},
  url = {https://en.wikipedia.org/wiki/Statistical_coupling_analysis},
  note = {License CC-BY-SA-4.0; archived copy https://metraipolis.com/documento/dc_07b7828f4e8c; sha256 7238ead4e073e0d894b72995174ef6695b6b93da9d1517965998829b1b7a8cd6},
  year = {2026}
}

Archived text

Reproduced under CC-BY-SA-4.0. Attribution: Wikipedia (en), https://en.wikipedia.org/wiki/Statistical_coupling_analysis. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Statistical Coupling Analysis (SCA) is a method used in bioinformatics to study how pairs of amino acids in a protein sequence evolve together. It analyzes a multiple sequence alignment (MSA), which is a display of the sequences of many related proteins arranged to highlight similarities and differences. SCA measures how much the amino acid makeup at one position in the protein changes when the amino acid makeup at another position is altered. This relationship is quantified as statistical coupling energy. A higher coupling energy indicates that the amino acids at both positions are more likely to have co-evolved and are therefore functionally or structurally linked. In simpler terms, it helps scientists understand which parts of a protein are working together and how they have changed over evolutionary time.

Tema degli esploratori: scienze della vita e salute (deposito sistematico; categoria «Bioinformatics»).
Fonte: Wikipedia in inglese, voce «Statistical coupling analysis» — https://en.wikipedia.org/wiki/Statistical_coupling_analysis
Wikidata Q7604386 (dati Wikidata in CC0 1.0) — https://www.wikidata.org/wiki/Q7604386
Autori: i contributori di Wikipedia (cronologia: https://en.wikipedia.org/wiki/Statistical_coupling_analysis?action=history).
Licenza: Creative Commons Attribuzione-Condividi allo stesso modo 4.0 (CC BY-SA 4.0) — https://creativecommons.org/licenses/by-sa/4.0/. Il riuso richiede attribuzione e stessa licenza.
Estratto dell'introduzione non modificato nel contenuto; revisione 1376393238, consultata il 2026-10-07T23:35:17.391Z tramite l'API ufficiale di Wikipedia. Impronta SHA-256 dell'estratto: 9a46eb18a67174bf7b0e16859547e091be1fd0b21139e87a0c0c74c36d1f14d4