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Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics — Europe PMC PMID:33830019

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/33830019
DOI: 10.7554/elife.66190
License (as archived): CC0-1.0
Archived: 2026-11-05T02:59:37.670Z
SHA-256 of the archived text: 3b8f6910feb9445fb0698f70a57f3b673dac145454879ee97f77ca2797b70a15
Stable URL of this page: https://metraipolis.com/documento/dc_05dec4dca47c

How to cite

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics — Europe PMC PMID:33830019 — Europe PMC (en), https://europepmc.org/article/MED/33830019 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_05dec4dca47c (Metraipolis archive dc_05dec4dca47c, sha256 3b8f6910feb9445fb0698f70a57f3b673dac145454879ee97f77ca2797b70a15)

BibTeX

@misc{dc05dec4dca47c,
  title = {Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics — Europe PMC PMID:33830019},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/33830019},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_05dec4dca47c; sha256 3b8f6910feb9445fb0698f70a57f3b673dac145454879ee97f77ca2797b70a15},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/33830019. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205 + /CD172a + conventional dendritic cells type 2 and upregulation of BM myeloid progenitor Ccr7 signaling. Mature myeloid Traf6 signaling is anti-inflammatory and necessary for lymph node myeloid cell development. This report unveils the existence and the mechanistic basis of a very early direct traffic of myeloid progenitors from BM to lymphatics during inflammation.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: eLife, 2021 (prima pubblicazione 2021-04-08).
Identificativi: PMID 33830019 · PMCID PMC8137144 · DOI 10.7554/elife.66190.
Parole chiave degli autori: Human; Bone marrow; Mouse; Inflammation; Circulation; Medicine; endotoxemia; immunology; lymphatics; Myeloid Progenitors.
Descrittori MeSH principali: Cell Movement.
Pagina: https://europepmc.org/article/MED/33830019 — https://doi.org/10.7554/elife.66190. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-05T02:53:19.812Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.