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Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice — Europe PMC PMID:39378227

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/39378227
DOI: 10.1371/journal.ppat.1012592
License (as archived): CC0-1.0
Archived: 2026-10-06T15:18:36.797Z
SHA-256 of the archived text: 39a47e4d77bcab580e7ed0fb805241b0b14d427cddf8054859dd38796500155d
Stable URL of this page: https://metraipolis.com/documento/dc_04fb7bebbfab

How to cite

Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice — Europe PMC PMID:39378227 — Europe PMC (en), https://europepmc.org/article/MED/39378227 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_04fb7bebbfab (Metraipolis archive dc_04fb7bebbfab, sha256 39a47e4d77bcab580e7ed0fb805241b0b14d427cddf8054859dd38796500155d)

BibTeX

@misc{dc04fb7bebbfab,
  title = {Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice — Europe PMC PMID:39378227},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/39378227},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_04fb7bebbfab; sha256 39a47e4d77bcab580e7ed0fb805241b0b14d427cddf8054859dd38796500155d},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/39378227. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis. Enhanced neutrophil infiltration is associated with higher susceptibility to Leishmania infection, but neutrophil effector response contribution to this phenotype is uncertain. Here, we show that neutrophils from susceptible BALB/c mice (B/c) produce more NETs in response to Leishmania major than those from resistant C57BL/6 mice (B6), which are more phagocytic. The absence of neutrophil elastase contributes to phagocytosis regulation. Microarray analysis shows enrichment of genes involved in NET formation (mpo, pi3kcg, il1b) in B/c, while B6 shows upregulation of genes involved in phagocytosis and cell death (Arhgap12, casp9, mlkl, FasL). scRNA-seq in L. major-infected B6 showed heterogeneity in the pool of intralesional neutrophils, and we identified the N1 subset as the putative subpopulation involved with phagocytosis. In vivo, imaging validates NET formation in infected B/c ears where NETing neutrophils were mainly uninfected cells. NET digestion in vivo augmented parasite lymphatic drainage. Hence, a balance between NET formation and phagocytosis in neutrophils may contribute to the divergent phenotype observed in these mice.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PLoS pathogens, 2024 (prima pubblicazione 2024-10-08).
Identificativi: PMID 39378227 · PMCID PMC11488723 · DOI 10.1371/journal.ppat.1012592.
Descrittori MeSH principali: Neutrophils; Mice, Inbred BALB C; Mice, Inbred C57BL; Leishmania major; Leishmaniasis, Cutaneous; Phagocytosis.
Pagina: https://europepmc.org/article/MED/39378227 — https://doi.org/10.1371/journal.ppat.1012592. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-06T15:11:56.334Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.