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Impact of clinical pathways on enhancing compliance with evidence-based therapies for Heart failure with reduced ejection fraction-A retrospective cohort study — Europe PMC PMID:40906662

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40906662
DOI: 10.1371/journal.pone.0330188
License (as archived): CC0-1.0
Archived: 2026-10-08T01:43:27.292Z
SHA-256 of the archived text: 4111ad8d4b961fa1d9faef2308334c4de8f84e8ea1d8bfff070ab3c4fef79ee9
Stable URL of this page: https://metraipolis.com/documento/dc_04bdb45dfd72

How to cite

Impact of clinical pathways on enhancing compliance with evidence-based therapies for Heart failure with reduced ejection fraction-A retrospective cohort study — Europe PMC PMID:40906662 — Europe PMC (en), https://europepmc.org/article/MED/40906662 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_04bdb45dfd72 (Metraipolis archive dc_04bdb45dfd72, sha256 4111ad8d4b961fa1d9faef2308334c4de8f84e8ea1d8bfff070ab3c4fef79ee9)

BibTeX

@misc{dc04bdb45dfd72,
  title = {Impact of clinical pathways on enhancing compliance with evidence-based therapies for Heart failure with reduced ejection fraction-A retrospective cohort study — Europe PMC PMID:40906662},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40906662},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_04bdb45dfd72; sha256 4111ad8d4b961fa1d9faef2308334c4de8f84e8ea1d8bfff070ab3c4fef79ee9},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40906662. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Background: Heart failure (HF) mortality is rising despite robust evidence-based guidelines. Hospitalization presents an opportune time to optimize care. Inpatient care pathways (CP) embedded in the electronic health record (EHR) can enhance adherence to guidelines by providing real-time decision support. Objective: To measure the impact of the heart failure reduced ejection fraction (HFrEF) CP on early diuretic use, goal-directed medical therapy (GDMT), and referral to comprehensive HF management (CHFM) on discharge. Methods: A HFrEF CP embedded into the EHR was built by multidisciplinary providers across a large academic medical center. Providers could place orders and document notes directly from the pathway. We conducted a retrospective cohort study of all the HF hospitalizations two years after pathway implementation and further limited the cohort to those with ejection fraction (EF) ≤ 40%. We compared rates of early diuretic use, GDMT, and referral to CHFM between cohorts defined by pathway use. Results: 1,639 patients contributed 2,062 hospitalizations. The pathway was opened in 362 (17.6%) hospitalizations. There were no significant clinical or sociodemographic differences between groups. Bivariate analyses revealed more GDMT (χ2 (1) = 3.651, p = 0.056); while multivariable analysis showed more early diuretics (OR = 1.58, 95% CI 1.19, 2.09, p = 0.002) and referrals to CHFM (OR = 3.24, 95% CI 2.54, 4.12, p < 0.001) in the pathway group. Conclusion: Despite low utilization, pathway use was associated with more early diuretics and referrals to CHFM with a trend toward more GDMT on discharge. CPs are a feasible strategy to optimize care for hospitalized HF patients.

Tema degli esploratori: ricerca e scienza aperta (ricerca Europe PMC «preprint», solo open access).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-09-04).
Identificativi: PMID 40906662 · PMCID PMC12410806 · DOI 10.1371/journal.pone.0330188.
Descrittori MeSH principali: Stroke Volume; Critical Pathways; Heart Failure.
Pagina: https://europepmc.org/article/MED/40906662 — https://doi.org/10.1371/journal.pone.0330188. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T01:17:01.537Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.