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Evaluation of a nanophosphor lateral-flow assay for self-testing for herpes simplex virus type 2 seropositivity — Europe PMC PMID:31821330

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/31821330
DOI: 10.1371/journal.pone.0225365
License (as archived): CC0-1.0
Archived: 2026-11-09T23:12:18.644Z
SHA-256 of the archived text: 31efa3765673bcf43d8c87dedab8472eebafbbe889299bdef0bf2d1c7a4635a4
Stable URL of this page: https://metraipolis.com/documento/dc_045795673306

How to cite

Evaluation of a nanophosphor lateral-flow assay for self-testing for herpes simplex virus type 2 seropositivity — Europe PMC PMID:31821330 — Europe PMC (en), https://europepmc.org/article/MED/31821330 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_045795673306 (Metraipolis archive dc_045795673306, sha256 31efa3765673bcf43d8c87dedab8472eebafbbe889299bdef0bf2d1c7a4635a4)

BibTeX

@misc{dc045795673306,
  title = {Evaluation of a nanophosphor lateral-flow assay for self-testing for herpes simplex virus type 2 seropositivity — Europe PMC PMID:31821330},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/31821330},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_045795673306; sha256 31efa3765673bcf43d8c87dedab8472eebafbbe889299bdef0bf2d1c7a4635a4},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/31821330. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Herpes Simplex Virus Type 2 (HSV-2) is a common human pathogen that causes life-long illness. The US prevalence of HSV-2 infection is 11.9% for individuals between 15 and 49 years of age. Individuals with HSV-2 infection are more likely to contract and spread other sexually-transmitted infections. Eighty percent of individuals with HSV-2 are unaware of their infection, in part because of the social stigma associated with in-clinic testing for sexually-transmitted infections. We conducted an initial evaluation of a prototype smartphone-based serological lateral-flow immunoassay (LFA) for HSV-2 infection that uses strontium aluminate persistent luminescent nanoparticles (nanophosphors) as reporters. When applied to a test panel of 21 human plasma/serum samples varying in anti-HSV titer, the nanophosphor HSV-2 LFA had 96.7% sensitivity and 100% specificity for detection of HSV-2 infection. The sensitivity of the nanophosphor HSV-2 LFA was higher than that of commercially-available rapid HSV-2 assays tested with the same panel. Analysis of the iPhone nanophosphor HSV-2 LFA strip images with our custom smartphone app gave greater reproducibility compared to ImageJ analysis of strip images. The smartphone-based nanophosphor LFA technology shows promise for private self-testing for sexually-transmitted infections (STI).

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2019 (prima pubblicazione 2019-12-10).
Identificativi: PMID 31821330 · PMCID PMC6903713 · DOI 10.1371/journal.pone.0225365.
Descrittori MeSH principali: Immunoassay.
Pagina: https://europepmc.org/article/MED/31821330 — https://doi.org/10.1371/journal.pone.0225365. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-11-09T23:09:22.666Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.