Metraipolis › archive › dc_044bba95e680

Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection — Europe PMC PMID:37463173

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37463173
DOI: 10.1371/journal.pone.0288803
License (as archived): CC0-1.0
Archived: 2026-10-07T12:57:51.091Z
SHA-256 of the archived text: 554277d8961473d3d34ae34081eaa7982d86f2c54170f75f4adeb0126339ed6b
Stable URL of this page: https://metraipolis.com/documento/dc_044bba95e680

How to cite

Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection — Europe PMC PMID:37463173 — Europe PMC (en), https://europepmc.org/article/MED/37463173 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_044bba95e680 (Metraipolis archive dc_044bba95e680, sha256 554277d8961473d3d34ae34081eaa7982d86f2c54170f75f4adeb0126339ed6b)

BibTeX

@misc{dc044bba95e680,
  title = {Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection — Europe PMC PMID:37463173},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37463173},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_044bba95e680; sha256 554277d8961473d3d34ae34081eaa7982d86f2c54170f75f4adeb0126339ed6b},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37463173. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Objectives: An isolated reduction in the diffusing capacity for carbon monoxide (DLco; iso↓DLco) is one of the most common pulmonary function test (PFT) abnormalities in people living with HIV (PWH), but its clinical implications are incompletely understood. In this study, we explored whether iso↓DLco in PWH is associated with a greater respiratory symptom burden. Study design: Cross-sectional analysis. Methods: We used ATS/ERS compliant PFTs from PWH with normal spirometry (post-bronchodilator FEV1/FVC ≥0.7; FEV1, FVC ≥80% predicted) from the I AM OLD cohort in San Francisco, CA and Seattle, WA, grouped by DLco categorized as normal (DLco ≥lower limit of normal, LLN), mild iso↓DLco (LLN >DLco >60% predicted), and moderate-severe iso↓DLco (DLco ≤60% predicted). We performed multivariable analyses to test for associations between DLco and validated symptom-severity and quality of life questionnaires, including the modified Medical Research Council dyspnea scale (mMRC), the COPD Assessment Test (CAT), and St. George's Respiratory Questionnaire (SGRQ), as well as between DLco and individual CAT symptoms. Results: Mild iso↓DLco was associated only with a significantly higher SGRQ score. Moderate-severe iso↓DLco was associated with significantly higher odds of mMRC ≥2 and significantly higher CAT and SGRQ scores. PWH with moderate-severe iso↓DLco had increased odds of breathlessness, decreased activity, lower confidence leaving home, and less energy. Conclusions: Iso↓DLco is associated with worse respiratory symptom scores, and this association becomes stronger with worsening DLco, suggesting that impaired gas exchange alone has a significant negative impact on the quality of life in PWH. Additional studies are ongoing to understand the etiology of this finding and design appropriate interventions.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-07-18).
Identificativi: PMID 37463173 · PMCID PMC10353811 · DOI 10.1371/journal.pone.0288803.
Descrittori MeSH principali: HIV Infections; Asthma; Lung Diseases; Pulmonary Disease, Chronic Obstructive.
Pagina: https://europepmc.org/article/MED/37463173 — https://doi.org/10.1371/journal.pone.0288803. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T12:28:09.545Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.