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The prevalence of neuropathic pain pathophysiology associated with ankle fracture: A study protocol — Europe PMC PMID:40828774

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/40828774
DOI: 10.1371/journal.pone.0327605
License (as archived): CC0-1.0
Archived: 2026-10-08T02:30:24.000Z
SHA-256 of the archived text: 2c94052380cb8d0ce07483fb00bfc3303eb946c469ce6e6151eb9e0f42d8f8de
Stable URL of this page: https://metraipolis.com/documento/dc_03cccefa4113

How to cite

The prevalence of neuropathic pain pathophysiology associated with ankle fracture: A study protocol — Europe PMC PMID:40828774 — Europe PMC (en), https://europepmc.org/article/MED/40828774 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_03cccefa4113 (Metraipolis archive dc_03cccefa4113, sha256 2c94052380cb8d0ce07483fb00bfc3303eb946c469ce6e6151eb9e0f42d8f8de)

BibTeX

@misc{dc03cccefa4113,
  title = {The prevalence of neuropathic pain pathophysiology associated with ankle fracture: A study protocol — Europe PMC PMID:40828774},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/40828774},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_03cccefa4113; sha256 2c94052380cb8d0ce07483fb00bfc3303eb946c469ce6e6151eb9e0f42d8f8de},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/40828774. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Chronic pain is prevalent among U.S. military personnel and often accompanied by comorbid behavioral health disorders and other medical conditions that further complicate its management. According to the Centers for Disease Control and Prevention, the prevalence of chronic pain among active-duty Service members is 1.5 to 2 times higher than the 20% of American adults who live with chronic pain. Recent report findings determined that Service members make up a large population within the Military Health Systems (MHS), and that this population is disproportionately affected by lost duty days, early retirement, loss of readiness, and increased burden to the MHS. To date, the Department of Defense (DOD) and MHS have emphasized multimodal, multidisciplinary, stepped treatment for chronic pain that prioritizes nonpharmacologic therapies and non-opioid pain medications. Though the DOD and MHS have invested in several pain treatment types, our level of understanding needs to better distinguish between acute and chronic pain and identify risk factors and mechanisms responsible for the chronification of pain, as it is the chronic pain which compromises functioning and readiness to a greater degree across the force. The novel information generated by this study will enhance our understanding of how ankle fracture elicits pathological risk factors for bone fracture associated neuropathic pain (BFNP), which ultimately impairs health-related quality of life. Due to the high prevalence of ankle fractures and the subsequent risk of developing chronic pain after ankle fracture, we will utilize this patient population to provide the preliminary evidence on whether bone fracture and subsequent BFNP phenotypes are reflected in specific genetic profiles and activated states of immune cells.

Tema degli esploratori: ricerca e scienza aperta (ricerca Europe PMC «preprint», solo open access).
Pubblicazione: PloS one, 2025 (prima pubblicazione 2025-08-19).
Identificativi: PMID 40828774 · PMCID PMC12364325 · DOI 10.1371/journal.pone.0327605.
Descrittori MeSH principali: Neuralgia; Ankle Fractures.
Pagina: https://europepmc.org/article/MED/40828774 — https://doi.org/10.1371/journal.pone.0327605. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-08T01:51:01.605Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.