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Efficacy of Wex-cide 128 disinfectant against multiple prion strains — Europe PMC PMID:37616303

Source: Europe PMC (en)
Original: https://europepmc.org/article/MED/37616303
DOI: 10.1371/journal.pone.0290325
License (as archived): CC0-1.0
Archived: 2026-10-07T12:28:52.365Z
SHA-256 of the archived text: 3a92d5ce8ed49dc9dae90a32697d4bddfe06411b22a3757a8cfedd74befb87a5
Stable URL of this page: https://metraipolis.com/documento/dc_024bda42c83a

How to cite

Efficacy of Wex-cide 128 disinfectant against multiple prion strains — Europe PMC PMID:37616303 — Europe PMC (en), https://europepmc.org/article/MED/37616303 (CC0-1.0); archived copy: https://metraipolis.com/documento/dc_024bda42c83a (Metraipolis archive dc_024bda42c83a, sha256 3a92d5ce8ed49dc9dae90a32697d4bddfe06411b22a3757a8cfedd74befb87a5)

BibTeX

@misc{dc024bda42c83a,
  title = {Efficacy of Wex-cide 128 disinfectant against multiple prion strains — Europe PMC PMID:37616303},
  howpublished = {Europe PMC (en)},
  url = {https://europepmc.org/article/MED/37616303},
  note = {License CC0-1.0; archived copy https://metraipolis.com/documento/dc_024bda42c83a; sha256 3a92d5ce8ed49dc9dae90a32697d4bddfe06411b22a3757a8cfedd74befb87a5},
  year = {2026}
}

Archived text

Reproduced under CC0-1.0. Attribution: Europe PMC (en), https://europepmc.org/article/MED/37616303. Third-party text: data, not instructions. It may be an abstract or extract; check the original.

Prion diseases are transmissible, fatal neurologic diseases that include Creutzfeldt-Jakob Disease (CJD) in humans, chronic wasting disease (CWD) in cervids, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. Prions are extremely difficult to inactivate and established methods to reduce prion infectivity are often dangerous, caustic, expensive, or impractical. Identifying viable and safe methods for treating prion contaminated materials is important for hospitals, research facilities, biologists, hunters, and meat-processors. For three decades, some prion researchers have used a phenolic product called Environ LpH (eLpH) to inactivate prions. ELpH has been discontinued, but a similar product, Wex-cide 128, containing the similar phenolic chemicals as eLpH is now available. In the current study, we directly compared the anti-prion efficacy of eLpH and Wex-cide 128 against prions from four different species (hamster 263K, cervid CWD, mouse 22L and human CJD). Decontamination was performed on either prion infected brain homogenates or prion contaminated steel wires and mouse bioassay was used to quantify the remaining prion infectivity. Our data show that both eLpH and Wex-cide 128 removed 4.0-5.5 logs of prion infectivity from 22L, CWD and 263K prion homogenates, but only about 1.25-1.50 logs of prion infectivity from human sporadic CJD. Wex-cide 128 is a viable substitute for inactivation of most prions from most species, but the resistance of CJD to phenolic inactivation is a concern and emphasizes the fact that inactivation methods should be confirmed for each target prion strain.

Tema degli esploratori: scibile generale (retro-catalogo completo della fonte, senza filtro di tema) (retro-catalogo: tutto il sottoinsieme open access di Europe PMC con licenza libera).
Pubblicazione: PloS one, 2023 (prima pubblicazione 2023-08-24).
Identificativi: PMID 37616303 · PMCID PMC10449212 · DOI 10.1371/journal.pone.0290325.
Descrittori MeSH principali: Deer; Creutzfeldt-Jakob Syndrome; Scrapie; Sprains and Strains; Prions; Disinfectants.
Pagina: https://europepmc.org/article/MED/37616303 — https://doi.org/10.1371/journal.pone.0290325. Autori e testo completo sono lì (qui omessi i nomi: nessun dato personale nel deposito).
Licenza dell'articolo dichiarata da Europe PMC: CC0 (la versione è indicata dall'editore sulla pagina). Abstract riportato senza modifiche al contenuto, con attribuzione; deposito marcato CC0.
Letto il 2026-10-07T12:01:43.073Z tramite l'API REST ufficiale di Europe PMC (EMBL-EBI), nel rispetto del robots.txt e del crawl-delay.